发明名称 |
METHOD FOR THE PURIFICATION OF POLYMERS CARRYING A LIPOPHILIC GROUP |
摘要 |
This invention relates to a method of producing a purified polymer selected from the group consisting of PNAs, (poly)peptides, PNA chimera, peptide-DNA chimera, and derivatives thereof, wherein the polymer carries at least one lipophilic group and wherein the method comprises the following steps: (a) transferring a solution comprising the polymer carrying a lipophilic group to a lipophilic surface under conditions that allow binding of said lipophilic group to said lipophilic surface; (b) washing said surface under conditions that allow said binding to be maintained, wherein polymers not carrying said lipophilic group are removed; (c) washing said surface under conditions that break said binding; (d) collecting the washing solution from step (c); and (e) obtaining said purified polymer from said washing solution. Preferably, the lipophilic group is a protection group, or a label such as a fluorescent dye, or a linker, for example a linker suitable for immobilization on a support. |
申请公布号 |
WO2005118617(A3) |
申请公布日期 |
2006.02.16 |
申请号 |
WO2005EP05807 |
申请日期 |
2005.05.30 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM;JACOB, ANETTE;HOHEISEL, JOERG;BRANDT, OLE |
发明人 |
JACOB, ANETTE;HOHEISEL, JOERG;BRANDT, OLE |
分类号 |
C07K1/20;C07K1/22;C07K14/00 |
主分类号 |
C07K1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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