A RECOMBINANT VIRUS COMPRISING BPI GENE AND A PHARMACEUTICAL COMPOSITION CONTAINING THE VIRUS AND USES THEREOF

摘要

The present invention discloses a recombinant virus, which comprises a viral vector, and a gene construct selected from the following: 1) a human BPI gene or a functional fragment gene thereof, or a degenerate Sequence thereof, and 2) a chimeric gene comprising a human BPI gene or a functional fragment gene thereof, or a degenerate Sequence thereof, wherein the chimeric gene further comprises a Fc constant region gene or its allelic gene of a heavy chain of a human immunoglobulin in the 3' end of the human BPI gene or the functional fragment gene thereof. This invention also discloses the use of the gene construct comprising the human BPI gene or functional fragment gene thereof in the preparation of the pharmaceutical composition of gene therapy of the GNB and/or GNB like pathogen infection in Mammal. The present invention further provides a gene therapy method of the GNB and/or GNB like pathogen infection using the recombinant virus or the pharmaceutical composition.