CYCLIC POLYAMINE CONTAINING NITROGEN ATOMS N IN RING PROTECTED BY PRINCIPLE ALL EXCEPT ONE (N-1) AND METHODS FOR THEIR PREPARING

摘要

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention describes novel cyclic polyamines of the following formulae: (XIV): wherein y = 1-5; p = 0; z = 3-11; m and m' are similar and mean a whole number from 0 to 2; n and n' are similar and mean a hole number from 1 to 2; E means hydrogen atom, phenylaminocarbonyl, benzyloxycarbonyl or toluenesulfonyl; Ar means 1,4-phenylene-bis-(C1-C2)-alkylene. Also, invention relates to methods for synthesis of these compounds providing protection of nitrogen atoms N by principle "(N-1)" with the high yield, i. e. all are protected except for one amino-group by using the specific perfluoro-containing agents that provides in subsequent light removal of protection. Also, invention discloses a novel method for synthesis of 1,1'-[1,4-phenylene-bis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane possessing anti-HIV activity. ^ EFFECT: improved methods of synthesis, valuable antiviral properties of compounds. ^ 22 cl, 3 dwg, 11 ex