发明名称 |
CROSS-SCREENING SYSTEM AND METHODS FOR DETECTING A MOLECULE HAVING BINDING AFFINITY FOR A TARGET MOLECULE |
摘要 |
The invention is directed to a cross-screening system and methods of the invention utilizing a combination of an immunoassay (IA) and electrochemiluminescence assay (ECLA) to identify molecules that have binding affinities for a target molecule. The cross-screening system and methods of the invention can detect molecules that have binding affinities for the target molecule below the detection limits of the individual immunoassay or ECLA. The cross-screening system and methods of the invention are useful for generating a pool of candidate analyte molecules enriched in a desired characteristic, such as low binding affinity for a target molecule. Low affinity antibodies identified by the cross-screening system and methods of the invention are useful, for example, in assessing the safety and efficacy of biological therapeutics. |
申请公布号 |
WO2005114218(A3) |
申请公布日期 |
2006.02.16 |
申请号 |
WO2005US16770 |
申请日期 |
2005.05.13 |
申请人 |
GENENTECH, INC.;YANG, JIHONG;QUARMBY, VALERIE, ELIZABETH |
发明人 |
YANG, JIHONG;QUARMBY, VALERIE, ELIZABETH |
分类号 |
C07K16/22;C07K16/28;C07K16/42;C12Q1/68;G01N33/48;G01N33/50;G01N33/53;G01N33/58;G01N33/68;G06F19/00 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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