DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CXC CHEMOKINE RECEPTOR 2 (CXCR2)

摘要

The invention provides a human CXCR2 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cancer disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of CXCR2 as well as pharmaceutical compositions comprising such compounds.