PROCESS FOR THE PREPARATION OF ATOMOXETINE HYDROCHLORIDE

摘要

The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC1 by adding HCl to a mixture of (R)-(-)-tomoxetine (S)-(+)­mandelate with an organic solvent, with or without a base and water.