| 摘要 |
FIELD: organic chemistry, medicine, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to novel derivatives of pyrrolidone of the formula (I): wherein Q means =N, =C(R24)-; X-Y means -CH2-CH2-, -CH=CH-, -CH2-O-; R1, R1.1 and R1.2 are chosen independently from group comprising hydrogen atom (H), halogen atom, halogen-(C1-C6)-alkyl, -CN, (C1-C6)-alkoxy group; R21, R22 and R23 are chosen independently of one another from group comprising H, halogen atom; R24 means H; R3 means -NHR6; R4 means H; R6 means -C(O)H, -C(O)-(C1-C3)-alkyl, -C(O)-halogen-(C1-C3)-alkyl, -C(O)O-(C1-C3)-alkyl, -C(O)-NH2, -SO2-(C1-C3)-alkyl, and also its individual isomers, racemic and nonracemic mixtures. Proposed compounds inhibit activity of monoamine oxidase B that allows its using in prophylaxis and treatment of disease mediated by monoamine oxidase B inhibitor, in particular, Alzheimer's disease and senile feeble-mindedness. ^ EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition. ^ 15 cl, 4 sch, 31 ex |
