| 发明名称 |
SURFACE EXPRESSION OF ENZYME IN GENE-DIRECTED PRODRUG THERAPY |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a therapeutic method for specifically attacking tumor cells of patients using a prodrug. <P>SOLUTION: The invention provides a two component system for use in association with one another comprising: (a) a (viral) vector capable of expressing an enzyme on the surface of a cell; and (b) a prodrug which can be converted into an active drug by a carboxypeptidase having no sugar chain (causing decrease in activity), useful in the treatment of tumours. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
| 申请公布号 |
JP2006042821(A) |
申请公布日期 |
2006.02.16 |
| 申请号 |
JP20050235444 |
申请日期 |
2005.08.15 |
| 申请人 |
CANCER RESEARCH CAMPAIGN TECHNOLOGY LTD |
发明人 |
SPRINGER CAROLINE J;MARAIS RICHARD |
| 分类号 |
C12N15/09;A61K31/13;A61K31/35;A61K31/44;A61K35/76;A61K38/46;A61K38/48;A61K38/55;A61K45/00;A61K47/48;A61K48/00;A61P35/00;A61P43/00;C07K14/71;C12N5/10;C12N9/12;C12N9/48;C12N9/50;C12N9/52;C12N15/57;C12R1/91 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
