发明名称 |
High-sensitivity magnetic marker used for immune response measurement |
摘要 |
Disclosed are a highly-sensitive magnetic marker for use in measuring an immunoreaction with a SQUID magnetic sensor and the preparation thereof. The magnetic marker is composed of a magnetic fine particle and a polymer encapsulating the particle, wherein the particle diameter of the magnetic fine particle (preferably ferrite Fe<SUB>3</SUB>O<SUB>4</SUB>) is 20 to 40 nm and the external the diameter of the magnetic marker is 40 to 100 nm, the polymer having carboxyl groups on the surface thereof. The magnetic maker for a SQUID magnetic sensor is prepared by causing the surface of a magnetic fine particle to adsorb a hydrophilic macromonomer (preferably polyvinylpyrrolidone) having a polymerizable vinyl group at the terminal thereof and having a molecular weight of 500 to 1000, and then adding a monomer of a hydrophilic vinyl compound having carboxyl group and a crosslinking agent for carrying out copolymerization reaction.
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申请公布号 |
US2006035388(A1) |
申请公布日期 |
2006.02.16 |
申请号 |
US20050534262 |
申请日期 |
2005.05.06 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
YOSHINAGA KOHJI;ENPUKU KEIJI |
分类号 |
G01N33/553;G01N33/543;G01N33/551 |
主分类号 |
G01N33/553 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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