USE OF MAGNETIC MATERIAL TO DIRECT ISOLATION OF COMPOUNDS AND FRACTIONATION OF MULTIPART SAMPLES

摘要

Methods for isolating a compound from a multipart, typically biological
sample. The methods
use at least one paramagnetic particle having an associated electronic charge
to bind compounds
with the opposite charge to form a particle/compound complex. Alternatively,
the paramagnetic
particles have a ligand or functional group with an affinity for a target
compound to form a
particle/compound complex. The complex can be immobilized by applying a
magnetic field to
the particle/protein complex. The sample may be further processed to obtain a
protein sample in
a more pure form or a sample depleted of select compounds.