发明名称 |
Interaction of Smad6 with Hox proteins and uses thereof |
摘要 |
The present invention describes a novel interaction between Smad6 and the Hox genes in nuclear transcriptional regulation following BMP signal transduction. The present invention further provides methods of using this novel Smad6/Hox protein interaction to regulate gene expression, regulate bone formation and control osteoporosis. Further provided are methods of screening for compounds that interfere with the novel Smad6/Hox protein interaction, thereby resulting in expression of a Hox protein-repressed gene and/or stimulating bone formation.
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申请公布号 |
US2006034843(A1) |
申请公布日期 |
2006.02.16 |
申请号 |
US20050227664 |
申请日期 |
2005.09.14 |
申请人 |
CAO XU;SHI XINGMING;BAI SHUTING |
发明人 |
CAO XU;SHI XINGMING;BAI SHUTING |
分类号 |
C12Q1/68;A61K38/17;A61K39/395;A61K48/00;C07H21/04;C12N15/00 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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