发明名称 |
Method for the production of 2-amino-4-chloro-6-alkoxypyrimidines |
摘要 |
The present invention provides a process for preparing 2-amino-4-chloro-6-alkoxypyrimidines by reacting the 2-amino-4,6-dichloropyrimidine with an alkali metal alkoxide or a mixture of alkali metal hydroxides and an alcohol, in which the reaction is effected in a polar aprotic solvent (or solvent mixture), the solvent is subsequently distilled off to an extent of >30% and the product is precipitated by adding water during or after the distillation. This process, in which the polar aprotic solvent used may in particular be acetone and which can be performed at temperatures between 5 and 60° C., allows 2-amino-4-chloro-6-alkoxypyrimidines and in particular 2-amino-4-chloro-6-methoxypyrimidine to be prepared in high yields and at simultaneously very marked purity in a particularly economically viable and environmentally benign manner.
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申请公布号 |
US2006035913(A1) |
申请公布日期 |
2006.02.16 |
申请号 |
US20050528959 |
申请日期 |
2005.03.22 |
申请人 |
HUBER SYLVIA;GUTHNER THOMAS;MOSER WOLFGANG;KRAMMER DORIS |
发明人 |
HUBER SYLVIA;GUTHNER THOMAS;MOSER WOLFGANG;KRAMMER DORIS |
分类号 |
A61K31/513;C07D239/46;C07D239/47 |
主分类号 |
A61K31/513 |
代理机构 |
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主权项 |
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地址 |
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