发明名称 |
TREATMENT OF HYPERPROLIFERATIVE DISEASE WITH SUPERANTIGENS IN COMBINATION WITH ANOTHER ANTICANCER AGENT |
摘要 |
<p>The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.</p> |
申请公布号 |
WO2006015882(A2) |
申请公布日期 |
2006.02.16 |
申请号 |
WO2005EP08815 |
申请日期 |
2005.08.12 |
申请人 |
ACTIVE BIOTECH AB;HEDLUND, GUNNAR;FORSBERG, GOERAN;WALLEN-OEHMAN, MARIE |
发明人 |
HEDLUND, GUNNAR;FORSBERG, GOERAN;WALLEN-OEHMAN, MARIE |
分类号 |
A61K38/00;C07K;C07K14/31 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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