<p>Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin C<SUB>H</SUB>2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.</p>
申请公布号
WO2006017647(A1)
申请公布日期
2006.02.16
申请号
WO2005US27705
申请日期
2005.08.03
申请人
TRANSTECH PHARMA, INC.;MJALLI, ADNAN, M.M.;TIAN, YE, E.;WEBSTER, JEFFREY, C.;ROTHLEIN, ROBERT
发明人
MJALLI, ADNAN, M.M.;TIAN, YE, E.;WEBSTER, JEFFREY, C.;ROTHLEIN, ROBERT