发明名称 |
PROSTHETIC GROUPS ATTACHED TO STANNYLATED POLYMERS FOR THE SYNTHESIS OF RADIOPHARMACEUTICALS |
摘要 |
<p>The present invention relates to compositions and methods for preparing radiopharmaceutical compounds in high chemical-purity and isotopic-purity. The present invention provides polymer-bound precursors to radiopharmaceutical compounds that can be converted to radiopharmaceutical compounds in one step. In a preferred embodiment, a radiopharmaceutical precursor is bound to a polymeric support via a prosthetic group comprising an alkenyl-tin bond. The radiopharmaceutical precursor is converted to a radiopharmaceutical compound in one step involving cleavage of the alkenyl-tin bond and incorporation of a radioisotope to form the radiopharmaceutical compound. Importantly, the polymeric support containing the toxic tin by-product can be easily removed from the radiopharmaceutical compound by filtration. The present invention can be used to install a large number of different radioisotopes. In a preferred embodiment, the radioisotope is 211At, 123I, or 131I.</p> |
申请公布号 |
EP1624901(A2) |
申请公布日期 |
2006.02.15 |
申请号 |
EP20040730617 |
申请日期 |
2004.04.30 |
申请人 |
THE UNIVERSITY OF WESTERN ONTARIO |
发明人 |
HUNTER, DUNCAN, H.;GAGNON, M., KAREN, J. |
分类号 |
A61K51/04;A61K51/08;A61K101/02;C07B59/00;C07F7/22;(IPC1-7):A61K51/04 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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