CHEMICAL COMPOUNDS.

摘要

Compounds of general formula (I) wherein: R₁ and R₂ are, independently of each other, selected from hydrogen, optionally substituted C_1-10alkyl, optionally substituted -CO-(C_1-10alkyl), optionally substituted C_3-10cycloalkyl, optionally substituted -CO-(C_3-10cycloalkyl), optionally substituted C_2-10alkenyl, optionally substituted -CO-(C_2-10alkenyl), optionally substituted aryl, and optionally substituted -CO-aryl, or R₁ and R₂ together represent an optionally substituted saturated or unsaturated C_1-10alkylidene group, or an optionally substituted saturated or unsaturated C_3-10cycloalkylidene group, or R₁ and R₂ together with the carbon atom to which they are attached represent an optionally substituted saturated or unsaturated organic ring containing 3, 4, 5, 6, 7 or 8 ring carbon atoms and optionally 1, 2 or 3 ring heteroatoms selected from O, N and S; R₃, which may be the same as, or different from, either of R₁ and R₂, is selected from optionally substituted C_1-10alkyl, optionally substituted C_3-10cycloalkyl, optionally substituted C_2-10alkenyl, and optionally substituted aryl; R₄, R₅ and R₆ are, independently of each other, selected from hydrogen, optionally substituted C_1-10alkyl, OH, optionally substituted C_1-10alkoxy, halo, optionally substituted aryloxy, optionally substituted (C_1-10alkyl)-S(O)_n- where n = 0, 1 or 2, optionally substituted aryl-S(O)_n- where n = 0, 1 or 2, or R₄ is hydrogen and R₅ and R₆ together represent an optionally substituted saturated or unsaturated organic chain containing 1, 2, 3, 4, 5, 6 or 7 chain carbon atoms and optionally 1, 2 or 3 chain heteroatoms selected from O, N and S, provided that the chain is at least 3 atoms long; with the proviso that, when R₁ = R₂ = hydrogen, then any optionally substituted C_1-10alkyl or optionally substituted C_2-10alkenyl for R₃ must have a branch point at one or more of the alpha and beta positions counted from the carbonyl group (or tautomeric form thereof) to which R₃ is attached; or a physiologically acceptable salt, complex or prodrug thereof; are disclosed per se and for use in the treatment or prophylaxis of hypersensitivity, smooth muscle disorders, spasmodic conditions, allergic conditions, inflammatory conditions and/or pain.