METHOD OF ALPHA-SELECTIVE GLYCOSYLATION

摘要

An ±-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecule, which is a monosaccharide or a reducing end of an oligosaccharide with two or more monosaccharide residues connected by glycosidic or a sugar chain and alcoholic hydroxyl group or thiol group, to obtain a sugar structure glycoside containing ±-glycoside at a high ratio, under the ring-shaped formation of a protective group in a silyl acetal structure over hydroxyl groups at positions 4 and 6 in the sugar structure. By the process, highly selective ±-glycosylation of sugar structure can be progressed in a simple and efficient manner.