| 摘要 |
1,4 Di-substituted piperidine muscarinic antagonists of formula (I) or an isomer, pharmaceutically acceptable salt, ester or solvate thereof, wherein X is a bond, -O-, -S-, -SO-, -SO2-, -CO-, -C(OR7)2-, -CH2-O-, -O-CH2-, -CH~CH- -CH2-, -CH(C1-C6 alkyl)-, -C(C1-C6 alkyl)2-, -CONRI17- -NR17CO-, -O- C(O)NR17-, -NR17C(O)-O-, -SO2NR17- or-NR17SO2-; R is cycloalkyl, optional ly substituted phenyl or optionally substituted pyridyl; R2 is H, alkyl, optionally substituted cycloalkyl, cycloalkenyl, t-butoxycarbonyl or optionally substituted piperidinyl; and the remaining variables are as defined in the specification , are disclosed. Compounds of formula (I) are useful for treating cognitive disorders such as Alzheimer's disease. Also disclosed are pharmaceutical compositions, methods of preparation and combinations of compounds of formula (I) with ACh'ase inhibitors.
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