STEREOSELECTIVE PROCESS FOR PREPARING .BETA.-ANOMER ENRICHED2-DEOXY-2,2-DIFLUORO-D-RIBOFURANOSYL-3,5-HYDROXY PROTECTED-1-ALKYL AND ARYLSULFONATE INTERMEDIATES

摘要

A stereoselective process for preparing a .beta.- anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5- hydroxy protected-1-alkyl and aryl sulfonate intermediates by contacting an .alpha.-anomer enriched 2-deoxy-2,2-difluoro-D- ribofuranosyl-3,5-hydroxy protected-1-fluoroalkyl and fluoroaryl sulfonate with a conjugate anion of a sulfonic acid containing the desired alkyl or aryl sulfonate.