| 摘要 |
A test kit for the quantitative determination of narcotic drugs comprising (A) series of sealed vessels, each vessel containing a deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, wherein the isotopologue differs from vessel to vessel and—wherein the quantities of the isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) series of sealed vessels, each vessel containing in exactly defined concentrations and quantities the same isotopologue in quantities which differ from vessel to vessel; wherein the free isotopologues are selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs and contain at least three stable isotopes selected from the group consisting of 13C, 15N and 18O in the molecule with a degree of labeling of at least 95 mol-%; the use of the test kit and a method for quantitatively determining narcotic drugs. |
| 主权项 |
1. A test kit for the quantitative determination of narcotic drugs, wherein the test kit comprises
(A) at least one series of sealed vessels, each vessel containing at least one deuterium free isotopologue of a narcotic drug in exactly defined concentrations and quantities, wherein at least one deuterium free isotopologue differs from vessel to vessel and wherein the quantities of at least one deuterium free isotopologue differ from vessel to vessel or are the same for all vessels; and/or (B) at least one series of at least two sealed vessels, each vessel containing in exactly defined concentrations and quantities at least one of the same deuterium free isotopologue in quantities which differ from vessel to vessel; the at least one deuterium free isotopologue being selected from narcotic drugs; prodrugs, salts, solvates, hydrates and polymorphs of narcotic drugs; salts, solvates, hydrates and polymorphs of said prodrugs; metabolites of narcotic drugs and their prodrugs, salts, solvates, hydrates and polymorphs; metabolites of said salts, solvates, hydrates and polymorphs of said prodrugs; and salts, solvates, hydrates and polymorphs of said metabolites; and containing in the deuterium free isotopologue molecule at least three stable isotopes selected from 13C, 15N and 18O with a degree of labeling of at least 95 mol-%. |
