| 摘要 |
<p>The present invention relates to methods and uses for preventing or treating hormone-dependent diseases, in particular breast cancer, in a mammal, by a combination of an antiprogestin, in particular the antiprogestin 11b- (4-acetylphenyl)- 17b-hydroxy- 17a- (1, 1, 2, 2, 2-pentafluoroethyl) -estra-4, 9-dien- 3-one or a pharmaceutically acceptable derivative or analogue thereof, and a pure antiestrogen, in particular a compound of general formula (I) as defined in the specification, for instance 11b -Fluoro -17a -methyl- 7a-{5- [methyl (8, 8, 9, 9, 9-pentafluorononyl) amino] pentyl} -estra-1, 3, 5(10) -triene- 3, 17b-diol. The invention further relates to pharmaceutical compositions comprising said combination.</p> |
