| 摘要 |
<p>A high-yielding method for racemisation of (S)-(+)- and (R)-(-) -10, 11- dihydro- l0- -hydroxy-5H -dibenz/b, f/azepine-5 -carboxamide and a useful intermediate, 10-chloro- 10, 11 dihydro-5H -dibenz/b, f/azepine-5 -carboxamide (VII) are disclosed. Also disclosed are methods for the racemisation of optically pure or optically enriched mixtures of (S)-(+)-10, 11-dihydro-l0- -hydroxy- 5H-dibenz/b, f/azepine-5 -carboxamide (I) and (R)-(-)-10, 11-dihydro-l0 -hydroxy-5H -dibenz/b, f/azepine-5- carboxamide (II) to racemic (??)-10,11-dihydro- 10-hydroxy-5H -dibenz/b, f/azepine-5- carboxamide (III).</p> |
