发明名称 |
АКТИВНАЯ ИММУНИЗАЦИЯ ДЛЯ СОЗДАНИЯ АНТИТЕЛ К РАСТВОРИМОМУ А-БЕТА |
摘要 |
The invention provides methods useful for effecting prophylaxis or treatment of Alzheimer's disease. Such methods entail administering A-beta fragments from a central or C-terminal regions of A-beta. Such fragments can induce a polyclonal mixture of antibodies that specifically bind to soluble A-beta without binding to plaques. The antibodies can inhibit formation of amyloid deposits of A-beta in the brain of a patient from soluble Abeta thus preventing or treating the disease. Fragment A-beta 15-24 and subfragments of 5-10 contiguous amino acids thereof are preferred immunogens due to their capacity to generate a high titer of antibodies. |
申请公布号 |
RU2005127429(A) |
申请公布日期 |
2006.02.10 |
申请号 |
RU20050127429 |
申请日期 |
2004.01.31 |
申请人 |
НЬЮРАЛАБ ЛИМИТЕД (BM);ВАЙЕТ (US) |
发明人 |
ЙЕДНОК Тэд (US);ВЭСКЕЗ Ники (US);СЬЮБЕРТ Питер А. (US) |
分类号 |
C12N15/85;A61K;A61K38/04;A61K39/00;A61K39/395;A61P25/28;C07K5/00;C07K16/18;C12N;C12N15/86 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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