| 摘要 |
The present invention relates to a method of preparing metal-carborane complexes comprising reacting a salt of the formula: [M(CO)3(X m)3](1 + 3m), wherein M is selected from a radioisotope of rhenium (Re), technetium (Tc) a nd any other radioisotope binding in the same fashion, X is the same of differe nt and is, independently, any suitable ligand and m is the formal charge for ligand X, with a nido-carborane or a closo-carborane in the presence of a hard base. I n an embodiment of the invention, the hard base is a source of fluoride. Such a method is useful for preparing complexes suitable for radioimaging and radiotherapy.
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