METHOD OF COATING MEDICAL DEVICES

摘要

Processes for coating implantable medical devices that improve the stability
of therapeutic agents contained within the coating. In one embodiment, the
process comprises: applying a primer coating on the implantable medical
device; preparing a basecoat solution comprising polymers and a therapeutic
agent and applying the basecoat solution to the implantable medical devices;
preparing a topcoat solution comprising at least one polymer and applying the
topcoat solution to the implantable medical devices coated with the basecoat
solution; applying a solvent to partially redissolve the topcoat and basecoat
while altering the surface finish and dissolution properties of the
therapeutic agent; and final processing the implantable medical devices,
including inspecting, packaging and sterilizing the coated medical devices.