DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH EOSINOPHIL SERINE PROTEASE 1 (PRSS21)

摘要

The invention provides a human PRSS21 which is associated with the infections, cardiovascular diseases, respiratory diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, reproduction diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, reproduction diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS21 as well as pharmaceutical compositions comprising such compounds.