DENGUE PROTEASE SUBSTRATES AND INHIBITORS

摘要

The invention provides substrate specificity profiles for dengue proteases. Optimal dengue protease substrate sequences, both to the prime side and non-prime side of the dengue protease recognition site, are disclosed herein. The dengue protease substrate sequences are used in designing substrates, inhibitors, and prodrugs. Dengue protease inhibitors based on substrate specificity are also provided.