DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH NAPSIN 1 (NAP1)

摘要

The invention provides a human NAP1 which is associated with the cardiovascular diseases, infections, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases, respiratory diseases and inflammation. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases, respiratory diseases and inflammation. The invention also features compounds which bind to and/or activate or inhibit the activity of NAP1 as well as pharmaceutical compositions comprising such compounds.