SYNTHETIC PEPTIDES CONTAINING THE MOTIF 'YWWLXP' AS ANTHRAX TOXIN ANTIDOTES

摘要

Specific inhibitors, in Multiple Antigen Peptide form, which inhibit the interaction between protective antigen and lethal factor and neutralize anthrax toxin in vivo. Anti protective antigen peptides were selected from a phage library by competitive panning with lethal factor. Selected 12mer peptides were synthesized in tetra-branched form and systematically modified to achieve peptides with higher affinity and inhibitory efficiency. Exemplary peptides are TLPYWWLTPSNP and NVMTYWWLDPPL.