摘要 |
Preparation of alpha-substituted cysteine derivatives takes place by acidic hydrolysis of thiazolidines, wherein the hydrolysis is effected in the presence of a further phase comprising an organic solvent and a vapor comprising water, acid, organic solvent and aldehyde is removed from the reaction mixture, or a vapor comprising water, acid and aldehyde is removed from the reaction mixture and the vapor or its condensate is subsequently contacted with a phase comprising an organic solvent. The process requires less hydrolysis time and allows for recycle and/or recovery of acid and by product aldehyde.
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