MATERIALS AND METHODS FOR MODULATING SIGNALLING BY ALPHA-V INTEGRIN MOLECULES

摘要

It is disclosed that the avß5 integrin mediates the proliferative signal provided by CD23 to pre-B cells. The region of CD23 which interacts with avß5 has been defined, and found to interact with a site on the integrin distinct from that which binds RGD. The invention provides methods for disrupting the interaction between CD23 and avß5 and methods of screening for chemical entities capable of disrupting this interaction.