发明名称 |
Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
摘要 |
Disclosed are compounds that exhibit high transport across the intestinal wall of an animal. The compounds may optionally be linked to drugs that are poorly absorbed or poorly transported across the intestinal wall after oral administration to provide for enhanced therapeutic, and optionally prolonged therapeutic, systemic blood concentrations of the drugs upon oral administration of the drug-compound conjugate. Also disclosed are pharmaceutical compositions containing and methods of using such compounds.
|
申请公布号 |
US2006030551(A1) |
申请公布日期 |
2006.02.09 |
申请号 |
US20050234310 |
申请日期 |
2005.09.26 |
申请人 |
XENOPORT, INC. |
发明人 |
BHAT LAXMINARAYAN;GALLOP MARK A.;JANDELEIT BERND |
分类号 |
C07J43/00;A61K31/58;C07J9/00;C07J31/00;C07J41/00;C07J53/00;C07J71/00 |
主分类号 |
C07J43/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|