METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF RNA SILENCING
摘要
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
申请公布号
WO2006015389(A2)
申请公布日期
2006.02.09
申请号
WO2005US29011
申请日期
2005.08.04
申请人
UNIVERSITY OF MASSACHUSETTS;ZAMORE, PHILLIP, D.;HUTVAGNER, GYORGY;SCHWARZ, DIANNE;SIMARD, MARTIN
发明人
ZAMORE, PHILLIP, D.;HUTVAGNER, GYORGY;SCHWARZ, DIANNE;SIMARD, MARTIN