METHOD OF PRODUCING OXALIPLATIN LIPOSOME FORM

摘要

The invention relates to pharmaceutics. A method comprises preparing an emulsion of oxaliplatin and a lipide film based on phospholipide and cholesterol, their mixing, homogenization in at least two steps, filtration, ultrafiltration, sterilyzing and lyophilization. The obtained result provides in standard and stability of the prepared formulation of liposomes (their size is presented in a narrow range), comprising oxaliplatin, high encapsulation of oxaliplatin in liposomes, product stability in a storage shelf life.