Topical compositions with hyaluronate lyase inhibitory activity, e.g. useful as skin care and cleansing products, comprises carboxy-functional lanostanoids

摘要

Topical compositions with hyaluronate lyase inhibitory activity comprises carboxy-functional lanostanoids and other cosmetic or pharmaceutical ingredients and excipients. ACTIVITY : Dermatological; Antibacterial; Fungicide; Antiseborrheic. MECHANISM OF ACTION : Hyaluronate lyase inhibitor. (25S)-(+)-12alpha -hydroxy-3alpha -methoxycarbonylacetyl-24-methyl-8,24(31)-lanostadien-26-oic acid gave 78% inhibition of hyaluronate lyase and 0% inhibition of bovine hyaluronidase at a concentration of 5 mu M.