发明名称 |
SMALL MOLECULE INHIBITORS FOR MRP1 AND OTHER MULTIDRUG TRANSPORTERS |
摘要 |
A method of potentiating the activity of a therapeutic drug, like a chemotherapeutic drug or an antibiotic, in a cell or tissue, by inhibiting the efflux capability of a multidrug transporter are disclosed. The method is useful in the treatment of a cancer by sensitizing tumor cells to a chemotherapeutic agent. Compounds capable of inhibiting an efflux capability of a multidrug transporter also are disclosed. |
申请公布号 |
WO2005113004(A3) |
申请公布日期 |
2006.02.09 |
申请号 |
WO2005US16832 |
申请日期 |
2005.05.13 |
申请人 |
THE CLEVELAND CLINIC FOUNFATION;THE UNIVERSITY OF NEW SOUTH WALES;GUDKOV, ANDREI;HABER, MICHELLE;NORRIS, MURRAY |
发明人 |
GUDKOV, ANDREI;HABER, MICHELLE;NORRIS, MURRAY |
分类号 |
A61K31/4196;A61K31/425;A61K31/454;A61K31/4709;A61K31/519;A61K31/522;A61K31/5377;A61K31/55 |
主分类号 |
A61K31/4196 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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