发明名称 |
BICYCLO 2,3-BENZODIAZEPINES AND SPIROCYCLICALLY SUBSTITUTED 2,3- BENZODIAZEPINES 23- 23- |
摘要 |
BET-protein-inhibitory, in particular BRD4-inhibitory bicyclo- and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), pharmaceutical compositions comprising the compounds according to the invention, and the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for tumour disorders, are described. Furthermore, the use of BET protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control is described. |
申请公布号 |
HK1214819(A1) |
申请公布日期 |
2016.08.05 |
申请号 |
HK20160102753 |
申请日期 |
2016.03.10 |
申请人 |
BAYER PHARMA AKTIENGESELLSCHAFT |
发明人 |
SIEGEL, Stephan;BURLE, Stefan;CLEVE, Arwed;HAENDLER, Bernard;FERNNDEZ-MONTALVN, Amaury Ernesto;MNNING, Ursula;KRAUSE, Sabine;LEJEUNE, Pascale;BUSEMANN, Matthias;KUHNKE, Joachim |
分类号 |
C07D;A61K;A61P |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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