METHOD OF INHIBITING DNase ACTIVITY OF DNase gamma, METHOD OF SCREENING INHIBITOR INHIBITING DNase ACTIVITY OF DNase gamma, AND DNase gamma INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide a method of inhibiting DNase activity of DNaseγ, a method of screening inhibitors inhibiting the DNase activity of DNaseγ, and an inhibitor inhibiting the DNase activity of the DNaseγ. SOLUTION: The DNase activity of the DNaseγcan be inhibited by bonding a substance to a domain corresponding to a DNA bonding pocket where one chain DNA bonding to the enzyme activity center of DNase I and one chain DNA on the different side, when the DNase I cuts DNA while dissociating two chain DNA. By utilizing the inhibiting method like this, such a screening that selecting the compound bonding to the DNaseγfrom a compound library and confirming whether it is possible or not to inhibit the DNase activity of the DNaseγ. A substance obtained by this can inhibit the DNase activity of the DNaseγ. COPYRIGHT: (C)2006,JPO&NCIPI