ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS

摘要

PROBLEM TO BE SOLVED: To provide alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds.SOLUTION: According to the present invention, 1,3-dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.SELECTED DRAWING: Figure 1