| 摘要 |
<p>The invention relates to 2-imidazo-benzothiazoles of general formula (I), wherein R1 is phenyl or a N and/or O containing heterocycle; R2 is an imidazol or an annulated imidazol, selected from the group consisting of formulae a), b), c), d) or e); R3 is hydrogen, phenyl, 2,3-dihydro-benzo [1,4] dioxin-6-yl, benzo [b] thiophen-3-yI, 3-methyl-benzo[b]thiophen-2-yl, thiophen-2-yl,thiophen-3-yl or thiophen-2-yl-methyl, R4 is hydrogen,-(CH2)nO-lower alkyl or lower alkyl; R5 is hydrogen, lower alkyl, halogen, morpholinyl, -NR'R", piperidinyl, optionally substituted by hydroxy, or is pyrrolidin- l-yl; R6 is hydrogen, benzyl or -(CH2)nO-lower alkyl, R7 is hydrogen, -C(O)O-lower alkyl, -C(O)-C6H4-halogen, -C(O)-C6H4-lower alkyl, -C(O)-lower alkyl, -C(O)-cycloalkyl, -C(O)-NR'R", -C(O)-(CH2)nO-lower alkyl, -S(O)2-lower alkyl, -(CH2)nO-lower alkyl, -C(O) -pyridin-4-yl, which ring may be substituted by lower alkyl, halogen-lower alkyl or by pyrrol-l-yl-methyl, or is -(CH2)n-C(O)- -NR'R"; RaCOE/RaCOEaCOE are independently from each other hydrogen, lower alkyl or -(CH2)n-tetrahydropyran-4-yl, X is -CH2-,-NRaCOEaCOEaCOE-or-O-; RaCOEaCOEaCOE is hydrogen, -C(O)-lower alkyl, -C(O)O-lower alkyl, -C(O)-C6H4CH3, or benzyl; n is 1or 2; and to pharmaceutically acceptable acid addition salts thereof. These compounds are adenosine receptor ligands and therefore suitable for tha treatment of diseases related to this receptor.</p> |
