发明名称 |
Treatment of inflammatory disease |
摘要 |
The immunoglobulin heavy chain binding protein BiP(GRP78), or a fragment thereof, provides a reagent for indicating the presence of rheumatoid arthritis (RA). The protein used is a recombinant BiP(GRP78) having a defined sequence. A prognostic and/or diagnostic test for RA may be an ELISA or a Western Blot that utilizes the BiP(GRP78) protein or a fragment thereof. Also disclosed are a method of testing for RA using BiP(GRP78) or a cDNA sequence coding therefor. Further disclosed is a method of treating RA by the BiP(GRP78) protein or corresponding cDNA.
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申请公布号 |
US6995240(B1) |
申请公布日期 |
2006.02.07 |
申请号 |
US20010806955 |
申请日期 |
2001.07.11 |
申请人 |
KING'S COLLEGE LONDON |
发明人 |
PANAYI GABRIEL STAVROS;CORRIGALL VALERIE MARY;BODMAN-SMITH MARK DUNCAN;FIFE MARK STEWART;LANCHBURY JEREMY SHAUN |
分类号 |
C07K14/47;G01N33/50;A61K38/00;A61K39/00;A61K48/00;A61P29/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/53 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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