发明名称 |
Nucleic acid capable of binding specifically to Ras target protein |
摘要 |
A novel nucleic acid (aptamer) which binds specifically to the target protein of Ras, more particularly, a novel RNA aptamer which binds specifically to Raf-1; a method for screening an RNA capable of binding specifically to the target protein of Ras which comprises selecting an RNA capable of binding to the target protein of Ras from a pool of RNAs having various base sequences; a method for regulating the signal transduction causing the proliferation or differentiation of cells by using the above-described nucleic acid; and medicinal compositions with the use of the same.
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申请公布号 |
US6995249(B1) |
申请公布日期 |
2006.02.07 |
申请号 |
US20000529397 |
申请日期 |
2000.09.26 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY CORPORATION |
发明人 |
YOKOYAMA SHIGEYUKI;HIRAO ICHIRO;SAKAMOTO KENSAKU |
分类号 |
C07H21/02;A61K38/00;C07H21/04;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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