发明名称 |
CODON-OPTIMIZED GENES FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN OLEAGINOUS YEASTS |
摘要 |
The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to ?-linolenic acid (GLA); a-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-?-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to ETA; eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA); and arachidonic acid (ARA) to EPA. Nucleic acid sequences encoding codon-optimized desaturases and elongases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the codon-optimized desaturase or elongases, and recombinant host microorganisms expressing increased levels of desaturase or elongase are described. |
申请公布号 |
WO2004101753(A3) |
申请公布日期 |
2006.02.02 |
申请号 |
WO2004US14442 |
申请日期 |
2004.05.07 |
申请人 |
E.I. DUPONT DE NEMOURS AND COMPANY;PICATAGGIO, STEPHEN, K.;ZHU, QUINN, QUN |
发明人 |
PICATAGGIO, STEPHEN, K.;ZHU, QUINN, QUN |
分类号 |
C07H21/04;C12N;C12N1/18;C12N9/02;C12N9/10;C12N15/74;C12P7/64;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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