Pyrimidine compounds

摘要

This invention features pyrimidine compounds of formula (I): R₁ is aryl, or heteroaryl; each of R₂ and R₄, independently, is R^c, halogen, nitro, cyano, isothionitro, SR^c, or OR^c; or R₂ and R₄, taken together, is carbonyl; R₃ is R^c, alkenyl, alkynyl, OR^c, OC(O)R^c, SO₂R^c, S(O)R^c, S(O₂)NR^cR^d, SR^c, NR^cR^d, NR^cCOR^d, NR^cC(O)OR^d, NR^cC(O)NR^cR^d; NR^cSO₂R^d, COR^c, C(O)OR^c, or C(O)NR^cR^d, R₅ is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O₂), or NR^c; Y is a covalent bond, CH₂, C(O), C-N-R^c, C-N-OR^c, C-N-SR^c, O, S, S(O), S(O₂), or NR^c; Z is N or CH; one of U and V is N, and the other is CR^c; and W is O, S, S(O), S(O₂), NR^c, or NC(O)R^c; in which each of R^a and R^b, independently, is H, alkyl, aryl, heteroaryl; and each of R^c and R^d, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.