PERMEATION DEVICE AND METHOD FOR REDUCING AQUEOUS BOUNDARY LAYER THICKNESSES

摘要

The invention provides a permeation device (2) comprising a receiving vessel (6) having an aperture adapted for receiving an insert well (4). Both the vessel (6) and well (4) are used as either donor or acceptor compartments for permeability assays. The vessel (6) or well (4) comprises a porous suppor (8)t, which may comprise biological or biomimetic materials, adapted for a molecular entity to permeate therethrough. In one embodiment, a stirring member (24) disposed in the vessel (6) can provide solution agitation to reduce aqueous boundary layer thickness adjacent to the support (8). Boundary layer thicknesses can be reduced by a device (2) of the invention to less than about 15 um such that a molecular entity permeating the support closely approximates