| 摘要 |
An isolated human anti-TNF-alpha antibody, or antigen-binding portion thereof, containing at least one high-affinity V<SUB>L </SUB>or V<SUB>H </SUB>antibody chain that is effective, when substituted for the corresponding V<SUB>L </SUB>or V<SUB>H </SUB>chain of the anti-TNF-alpha scFv antibody having sequence SEQ ID NO: 1, to bind to human TNF-alpha with a K<SUB>off </SUB>rate constant that is at least 1.5 fold lower than that of the antibody having SEQ ID NO: 1, when determined under identical conditions.
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