Water-soluble derivatives of lipophilic drugs

摘要

A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): G-(L)_n-Y (I); where G is a lipophilic drug, L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms, n is 0 or 1, and Y is a water-solubilizing group such as -SO₃^-, -NR-SO₃^-, -P(-O)(OH)(O^-), or -O-P(-O)(OH)(O^-), where R is H or an alkyl group of 1 to 10 carbon atoms.