A system for expressing antigenic polypeptides in oligomeric form fuses the antigenic polypeptide to an oligomerisation polypeptide such that the oligomerisation polypeptide can interact with other oligomerisation polypeptides and bring multiple copies of the antigenic polypeptide into close proximity in the form of an oligomer. Expressing the polypeptides in oligomeric form in this way can improve their immunogenicity compared to a monomeric form.
申请公布号
WO2006011060(A2)
申请公布日期
2006.02.02
申请号
WO2005IB02528
申请日期
2005.07.22
申请人
CHIRON SRL;CAPECCHI, BARBARA;MASIGNANI, VEGA;RAPPUOLI, RINO;SCARSELLI, MARIA
发明人
CAPECCHI, BARBARA;MASIGNANI, VEGA;RAPPUOLI, RINO;SCARSELLI, MARIA