WATER-SOLUBLE CANNABINOIDS

摘要

Water-soluble cannabinoid compounds that are agonists of CB<SUB>1</SUB> and CB<SUB>2</SUB> cannabinoid receptors are provided. The compounds are made water-soluble by derivatization of the alkyl side chain and/or the phenolic hydroxyl group of tetrahydrocannabinol. The water-soluble cannabinoids are useful for the treatment of appetite loss, pain, multiple sclerosis, nausea and vomiting, and epilepsy.