发明名称 |
RADIOLABELED NANOHYBRIDS TARGETING SOLID TUMOR NEOVASCULATURE AND METHOD OF USING SAME |
摘要 |
<p>Nanohybrid polymer conjugates that provide a "platform" delivery system is disclosed. The delivery platform provides a multi-focused therapeutic regimen that may be tailored to combat a host of cancers, including advanced-stage, therapy-resistant tumors. The nanohybrids of the instant invention incorporate a configurable polymeric backbone, are multivalent (e.g., may incorporate several targeting ligands), and have the capacity to carry multiple classes of "payloads" (e.g., alpha-, beta-, gamma- and positron- emitting isotopes). The polymer conjugates comprise a single molecular species that can be useful not only in diagnostic assessment, but also in tailoring therapies to suit a variety of cancers.</p> |
申请公布号 |
WO2006012355(A2) |
申请公布日期 |
2006.02.02 |
申请号 |
WO2005US22666 |
申请日期 |
2005.06.28 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;LINE, BRUCE, R.;GHANDEHARI, HAMIDREZA;BAKLANOV, SERGEY |
发明人 |
LINE, BRUCE, R.;GHANDEHARI, HAMIDREZA;BAKLANOV, SERGEY |
分类号 |
A61K51/00 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|